HOPE worldwide is an international charity, headquartered in Philadelphia, Pennsylvania (USA), that operates sustainable, high-impact, community-based programs in more than 60 countries around the world.

HOPE worldwide provides full management services to the SHCH.  This includes recruiting medical and administrative personnel to help develop the hospital and train its Cambodian staff for long-term sustainability, and the provision of more than $20 million worth each year of medical supplies and medicines.

The Sihanouk Hospital Corporation, a Delaware tax-exempt non-profit corporation, was established to provide an organizational structure for the operation and governance of the Sihanouk Hospital Center of HOPE.